11, February 2016

Andriol: Instruction for medical use of the drug

Content

 

  1. Description of the pharmacological action
  2. Indications
  3. release Form
  4. Pharmacodynamic drug
  5. Pharmacokinetics
  6. Contraindications
  7. Side effects
  8. Dosing and Administration
  9. while taking precautions
  10. Storage conditions
  11. Shelf life

Description of the pharmacological action

It replenishes deficiency of endogenous testosterone. Regulates protein, nitrogen, phosphorus metabolism, stimulates the development of male reproductive organs and secondary sexual characteristics.

Indications

Hormone replacement therapy: post-castration syndrome, syndrome, hypopituitarism, endocrine impotence, menopausal disorders in men (including reduced libido, mental and physical activity), osteoporosis (in the background of androgen deficiency). Read more

release Form

40 mg capsules; vial (bottle) 60 plastic, carton (box) 1.

40 mg capsules; vial (bottle) 30 plastic, carton (box) 1.

Similar effects on drugs:

 

  • Omnadren 250 (Omnadren 250) Injection
  • Proviron (Proviron) oral tablets
  • Androgel (Androgel) Gel for external application
  • Sustanon-250 (Sustanon 250) A solution for intramuscular injection
  • Nebido (Nebido) solution for intramuscular injection
  • Nemestran (Nemestran) Capsule
  • Methyltestosterone (Methyltestosterone) oral tablets
  • Sustanon-250 (Sustanon 250) Injection
  • TK Andriol (Andriol TK) Capsule

 

pharmacodynamics

Androgenic means also has anabolic effects. The target cells (skin, prostate, seminal vesicles, epididymis) recovering the 5-alpha-reductase to 5a-dihydrotestosterone, which specifically interacts with the receptor on the cell surface and penetrates into the nucleus. In some tissues (including the hypothalamus) is converted to estradiol. In men, it stimulates the development and activity of the gonads, prostate, seminal vesicles, the formation of secondary male characteristics (height, deep voice, growth of beard and mustache), increases libido and potency; indirectly, through the central nervous system, affects sexual behavior. It reduces fat deposition and removal of trace elements. It suppresses the production and release of pituitary LH and FSH. It has anabolic effects: involved in skeletal growth, increases the mass of skeletal muscles; inhibits nitrogen, phosphorus, K +, sulfur needed for protein synthesis.

Pharmacokinetics

Increases testosterone and its active metabolites in the plasma, as It does not undergo hepatic metabolism primary, deposited in the lymphatic system, while retaining its activity.

Contraindications

prostate carcinoma or breast cancer (including suspected).

Side effects

Priapism (and other signs of excessive sexual stimulation); sodium and water retention; in prepubertal boys – accelerated sexual development, increased frequency of erections, penis enlargement, premature closure of the epiphysis.

Dosing and Administration

Inside, the food, the capsule is swallowed whole, without chewing, with a small amount of liquid. Starting dose – 120-160 mg per day (half dose in the morning and the other half – in the evening, when receiving an odd number higher dose capsule taken in the morning) for 2-3 weeks, then – 40-120 mg per day.

while taking precautions see more

When androgen-dependent adverse reactions treatment should be stopped and after their disappearance appoint smaller doses. Patients with latent or overt cardiac failure, renal dysfunction, hypertension, epilepsy, migraine (including history) should be under constant medical supervision. With care use in prepubertal boys.

Storage conditions

List B .: At a temperature of 2-8 ° C.

Shelf life

36 months.

Belonging to the ATX-classification:

G Mochepolovaya system and sex hormones

 

G03 Sex hormones and modulators of the genital system

 

G03B Androgens

 

G03BA derivatives of 3-oxoandrost

 

G03BA03 Testosterone